Synthesis of enantiomerically pure, partly saturated (RS)-[(1S)-isoborneol-10-sulfinyl]-substituted [1,2,4]triazolo[1,2-a]pyridazine, cinnolines and benzo[f]cinnolines
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منابع مشابه
A General Method for the Synthesis of Enantiomerically Pure â-Substituted, â-Amino Acids through r-Substituted Succinic Acid Derivatives
A general procedure for the synthesis of enantiopure â-substituted, â-amino acids is presented. Alkylation of the sodium enolates derived from chiral N-acyloxazolidinone imides 2 (R ) Me, i-Pr, t-Bu, Ph, Bn) with tert-butyl bromoacetate afforded the 2-substituted succinate derivatives 3 in good yields (82-89%) and with high selectivity (g93:7). Following hydrolysis, Curtius rearrangement of the...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2004
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0005.107